STAT3-derived EIF4E3 Activates TGF-β-SMAD2/3 Pathway

Nature · science

Researchers have identified that STAT3-derived EIF4E3 plays a crucial role in H2O2-induced human trabecular meshwork (HTM) cell injury. This process is facilitated by the activation of the TGF-β-SMAD2/3 pathway. Understanding this mechanism is vital as HTM cell dysfunction is a key factor in glaucoma pathogenesis. The study explores EIF4E3's functions and regulatory mechanisms, highlighting its potential role in glaucomatous conditions.